Process for preparing 3alpha, 7beta-dihydroxy-5beta-cholanic acid

摘要

Process to reduce stereoselectively 3alpha-hydroxy-7-keto-5beta-cholanic acid to 3alpha,7beta-dihydroxy-5beta-cholanic acid in ter.alcohols by using, as reducing agent, sodium metal in the presence of other metal salts. Examples of metal salts particularly useful are: potassium, cesium and rhubidium organic salts and, more particularly, potassium acetate or potassium ter.butylate.