| 摘要 |
<p>The invention concerns thromboxane synthetase inhibitors of the formula I <IMAGE> wherein R1 represents hydrogen or lower alkyl; Ar represents pyridyl unsubstituted or substituted by lower alkyl, carboxy, lower alkoxycarbonyl or carbamoyl; R2 and R3 independently represent hydrogen, lower alkyl, halogen, trifluoromethyl, hydroxy, lower alkoxy, carboxy lower alkyl, lower alkoxycarbonyl lower alkyl, carboxy, lower alkoxycarbonyl, or lower alkyl(thio, sulfinyl or sulfonyl), or R2 and R3 together on adjacent carbon atoms represent lower alkylenedioxy; A represents alkylene of 1 to 12 carbon atoms, alkenylene of 2 to 12 carbon atoms, alkynylene of 2 to 12 carbon atoms, lower alkylenephenylene lower alkylene, lower alkylenephenylene, phenylene lower alkylene, phenylene, a direct bond, lower alkylene-(thio or oxy)-lower alkylene-(thio or oxy)-phenylene, lower alkylene-(thio or oxy)-phenylene, phenylene-(thio or oxy)-lower alkylene or phenylene lower alkenylene; B represents carboxy, lower alkoxy-carbonyl, carbamoyl, mono- or di-lower alkylcarbamoyl, hydroxymethyl, hydroxycarbamoyl, 5-tetrazolyl or formyl; the N-oxides and salts thereof. They are prepared, for example, by ring closing a compound of the formula <IMAGE></p> |
