PROCESS FOR THE PREPARATION OF CHOLECALCIFEROL DERIVATIVES

摘要

for the Contracting States BE, CH, DE, FR, GB, IT, LI, NL 1. A process for the manufacture of 1 alpha,23(R),25-trihydroxycholecalciferol of the formula see diagramm : EP0115314,P14,F1 characterized by a) reacting a compound of the formula see diagramm : EP0115314,P15,F2 wherein R**1 and R**2 are hydrogen, lower alkyl or aryl or together are C3 -6 -alkylene, with a compound of the formula see diagramm : EP0115314,P15,F3 Wherein R**3 is lower alkyl or aryl, to give a compound of the formula see diagramm : EP0115314,P15,F4 wherein R**1, R**2 and R**3 have the above significance, and b) cleaving off the protecting groups from the compound of formula IV. For the contracting state AT 1. A process for the manufacture of 1 alpha,23(R),25-trihydroxycholecalciferol of the formula see diagramm : EP0115314,P16,F1 characterized by a) reacting a compound of the formula see diagramm : EP0115314,P17,F2 wherein R**1 and R**2 are hydrogen, lower alkyl or aryl or together are C3 -6 -alkylene, with a compound of the formula see diagramm : EP0115314,P17,F3 Wherein R**3 is lower alkyl or aryl, to give a compound of the formula see diagramm : EP0115314,P17,F4 wherein R**1, R**2 and R**3 have the above significance, and b) cleaving off the protecting groups from the compound of formula IV.