| 摘要 |
NEW MATERIAL:A compound of formula (R1 is H, alkali or alkaline earth metal; Q1-Q3 are N, C where at least two are N; R2 is H, lower alkyl; Ac is acyl) and its salt. EXAMPLE:7beta-[ 2-( 2-Aminothiazol-4-yl )-2- { ( imidazol-4-yl )-methoxyimino } acetamide]-3-acetoxymethyl-3-cephem-4-carboxylic acid dihydrochloride. USE:Antibacterial: it has antibacterial activity against gram-positive and -negative bateria. It shows its activity against Pseudomonas erginosa, which is resistant to conventional cephem compounds. PREPARATION:A compound of formula II (R3 is H, carboxyl-protecting group such as tert.-butyl) is acylated with a compound of formula III (R4 is H, amino- protecting group; R5 is H, lower alkyl, protecting group) to give an intermediate of formula IV, then deprotection is effected.
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