发明名称 AZIDIRINO DERIVATIVES OF TETRAMERIC CYCLOPHOSPHAZENES
摘要 An aziridino derivative of a tetrameric cyclochlorophosphazene compound having the formula N4P4Cl8-nAzn, in which Az represents aziridino and n = 1, 2, 3, 4, 5, 6 or 7; a process for bonding such an aziridino derivative by aminolysis in a reaction solution of a compound having the formula N4P4Cl8-nAzn, in which n = 0, 1, 2, 3, 4, 5, or 6, and recovering the resulting aziridino derivative by means of "high performance liquid chromatography" as well as an aziridino derivative - based on the resulting aziridino derivative - of a tetrameric substituted cyclophosphazene compound having an anti-tumor acitivity and having the formula N4P4R8-nAzn, in which n = 1, 2, 3, 4, 5, 6 or 7 and R represents the same or different substituents.
申请公布号 WO8404523(A1) 申请公布日期 1984.11.22
申请号 WO1984NL00013 申请日期 1984.05.07
申请人 RIJKSUNIVERSITEIT TE GRONINGEN 发明人 VAN DE GRAMPEL, JOHAN, CHRISTOPH;VAN DER HUIZEN, ADRIAAN, ALBERT
分类号 A61K31/675;C07F9/6581 主分类号 A61K31/675
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