发明名称 |
Polypeptides containing interferon-beta-1a mutants, their encoding nucleic acid molecules, host cells transformed by these molecules, method for the manufacture of polypeptides, polypeptides containing pharmaceutical compounds and polypeptide applications |
摘要 |
A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptide other than glycosylated interferon-beta. It is preferred that X is human interferon-beta-1a. Mutants of interferon-beta-1a are also described. |
申请公布号 |
PL200586(B1) |
申请公布日期 |
2009.01.30 |
申请号 |
PL19990347932 |
申请日期 |
1999.10.15 |
申请人 |
BIOGEN IDEC MA INC. |
发明人 |
RUNKEL LAURA;BRICKELMAIER MARGOT;WHITTY ADRIAN;HOCHMAN PAULA |
分类号 |
C07K14/565;C12N15/09;A61K38/00;A61K38/21;A61P9/00;A61P9/10;A61P31/12;C07K17/08;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/62;C12P21/02 |
主分类号 |
C07K14/565 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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