| 摘要 |
PURPOSE:To obtain optically active alpha-cyano-3-phenoxy-4-fluorobenzyl alcohol, by treating (R,S)-alpha-cyano-3-phenoxy-4-fluorobenzyl alcohol with specific esterase. CONSTITUTION:A bacterium belonging to the genus Arthrobacter, Achromobacter, etc. is cultivated to give esterase to be reacted with an organic carboxylic acid ester of (R,S)-alpha-cyano-3-phenoxy-4-fluorobenzyl alcohol, capable of subjecting preferentially an organic carboxylic acid ester of (S)-form alcohol to asymmetric hydrolysis. The organic carboxylic acid ester of (R,S)-form alcohol is reacted with the esterase at <=7pH, asymmetrically hydrolyzed, to give alpha-cyano-3-phenoxy-4-fluorobenzyl alcohol.
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