Spiro(indolo(1,7-ab)(1,5)benzodiazepine-2,4'-piperidines) and intermediates, a process for the preparation thereof and their use as medicaments.

摘要

The present invention relates to spiro [indolo [1, 7-ab] [1, 5] benzodiazepine-2, 4 min -piperidines] of the formula
<CHEM>
wherein p is 1 or O, g is 0 or 1 with the proviso that q is O if p is 1 and q is 1 if p is O, R1 is hydrogen or methyl and R is hydrogen or -CO(CH2)n NR2R3, R2 and R3 being each hydrogen or methyl but at least one of the two being methyl, and n being 1 or 2, which are useful as analgetic agents; intermediate compounds therefor; and methods for synthesizing the foregoing compounds. The compounds of the invention are useful as analgesic agents.