Islets-activating protein derivatives.

摘要

A derivative of Islets-Activating Protein having an insulin secretion promoting action is prepared by reacting an Islets-Activating Protein with a carbonyl compound of the formula:
R1 - @ - R2

wherein R1 is hydrogen atom, methyl group or
group and R2 is hydrogen atom or alkyl group

of 1 to 3 carbon atoms,
in the presence of a reducing agent. The derivatives thus obtained are useful in the treatment of diabetes and as a pertussis vaccine.