发明名称 |
PROCESS FOR THE PREPARATION OF ORTHO-TRIFLUOROMETHYL ANILINE |
摘要 |
A process for preparing orthotrifluoromethyl aniline from trifluoromethyl benzene is disclosed. The steps are (a) reacting the trifluoromethyl benzene with gaseous chlorine in the presence of a chlorination catalyst until at least 90% of the trifluoromethyl benzene is consumed; (b) nitrating the crude mixture from step (a) using a mixture of sulfuric acid and nitric acid until disappearance of the chlorotrifluoromethyl benzenes; (c) settling and washing the organic phase from step (b); (d) subjecting the organic phase from step (c) to a first hydrogenation under pressure in the presence of a hydrogenation catalyst consisting of Raney nickel and/or Raney nickel doped with chromium, in an organic-solvent medium until complete disappearance of the chloronitrotrifluoromethyl benzenes; (e) subjecting the mixture from step (d) to a second hydrogenation in the presence of an additional amount of Raney nickel and in the presence of at least one alkaline base; and (f) removing the orthotrifluoromethyl aniline by distillation from the reaction mixture. |
申请公布号 |
EP0054464(B1) |
申请公布日期 |
1984.11.21 |
申请号 |
EP19810401905 |
申请日期 |
1981.12.02 |
申请人 |
RHONE-POULENC SPECIALITES CHIMIQUES |
发明人 |
DISDIER, CAMILLE;MARTINAUD, JACQUES-PIERRE;SULLIVAN, JOHN |
分类号 |
C07B61/00;A01N33/06;B01J25/02;B01J27/00;B01J27/10;B01J29/00;C07C;C07C67/00;C07C209/00;C07C209/36;C07C211/52 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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