发明名称 |
POLYMORPHOUS FORMS OF RIFAXIMIN AS ANTIBIOTICS |
摘要 |
<p>Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin alpha and rifaximin beta , and a poorly crystalline form named rifaximin y have been discovered. These forms are useful in the production of medicinal preparations for oral and topical use and can be obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by the addition of water at a determinate temperature and for a determinate period of time. The crystallization is followed by drying carried out under controlled conditions until a specific water content is reached in the end product.</p> |
申请公布号 |
HK1092151(A1) |
申请公布日期 |
2009.05.08 |
申请号 |
HK20060113864 |
申请日期 |
2005.08.04 |
申请人 |
ALFA WASSERMANN S.P.A. |
发明人 |
VISCOMI, GIUSEPPE C.;CAMPANA, MANUELA;BRAGA, DARIO;CONFORTINI, DONATELLA;CANNATA, VINCENZO;SEVERINI, DENIS;RIGHI, PAOLO;ROSINI, GOFFREDO` |
分类号 |
A61K31/44;A61K;A61K31/395;A61K31/4188;A61K31/4353;A61K31/437;A61P;A61P31/00;A61P31/04;C07D;C07D498/22 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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