| 摘要 |
NEW MATERIAL:11beta-Hydroxypregn-4-en-3-one-20-carbaldehyde. USE:An intermediate for producing 11beta-hydroxypregn-4-ene-3,20-dione which is a synthetic intermediate for corticoid based steroid as an anti-inflammatory agent. PREPARATION:A bacterium, e.g. Alcaligenes faecalis D4020-K15 (FERM-P No. 204), belonging to the genus Alcaligenes is cultivated in a culture medium containing 11beta-hydroxylithocholic acid and/or a salt thereof (preferably 2-50g/l concentration) preferably at 25-35 deg.C for 10hr-7 days by the shaking culture or spinner culture method with aeration.
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