| 摘要 |
PURPOSE:To obtain the titled complex effective as a thrombolytic drug having both fibrin absorption ability and urokinase activity, by reacting fibrin adsorbing protein with urokinase in the presence of a specific reagent for protein bonding. CONSTITUTION:Fibrin adsorbing protein (e.g., plasmin HC, etc.) is reacted with urokinase in the presence of a protein bonding reagent shown by the formula (R is phenylene, or cycloalkylene; A is lower alkylene; B is lower alkylene which may contain lower alkylthio or phenyl lower alkylthio; l, m and n are 0, or 1, with the proviso that =m=nnot equal to 0) in a buffer solution at 4-10pH at 0-40 deg.C, to give a fibrin adsorption protein-urokinase complex. A thrombolytic drug containing 0.01-30wt% of this complex based on the whole composition. A dose is preferably 1,000-500,000 unit/kg/day calculated as the derivative and the drug is administered 2-4 times dividedly.
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