摘要 |
A crystalline tolterodine acid addition salt is provided to be useful as a pharmaceutical composition for treatment of urinary incontinence as a crystalline acid addition salts suitable for the manufacture of transdermal agent. An acid addition salt is tolterodine hippurate represented by chemical formula 3, tolterodine hemi-adipate represented by chemical formula 4, tolterodine gentisate represented by chemical formula 5, tolterodine benzene sulfonate represented by chemical formula 6, tolterodine p-toluenesulfonate represented by chemical formula 7, tolterodine L-pyroglutamate represented by chemical formula 8, tolterodine benzoate represented by chemical formula 9, tolterodine hemi-naphthalene-1,5-disulfonate represented by chemical formula 10, or tolterodine 1-hydroxy-2-naphthoate represented by chemical formula 11, and tolterodine glycolate represented by chemical formula 12 or tolterodine retinoate represented by chemical formula 13.
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