| 摘要 |
A diaz(ep)ine bis(N-amidinoamidine) derivative of the formula:- <CHEM> or a tautomeric form thereof, wherein R<1><0>, R<1><1>, R<1><2>, R<1><3>, R<1><4>, R<1><5>, R<1><6> and R<1><7>, which may be the same or different, are each hydrogen, a 1-16C alkyl radical, a 3-18C cycloalkyl or cycloalkylalkyl radical, or an optionally-substituted phenyl (1-4C alkyl) radical, or R<1><0>, R<1><1> and the nitrogen atom to which they are attached, or R<1><2> and R<1><3> and the nitrogen atom to which they are attached, or R<1><4> and R<1><5> and the nitrogen atom to which they are attached, or R<1><6> and R<1><7>, and the nitrogen atom to which they are attached, which may be the same or different, are each a 1-azetidinyl, 1-pyrrolidinyl, piperidino, hexamethyleneimino, heptamethyleneimino, morpholino or 4-(1-8C alkanoyl)-1-piperazinyl radical, or R<1><0> and R<1><4> together with the two nitrogen atoms to which they are attached and the intervening carbon atom, or R<1><2> and R<1><6> together with the two nitrogen atoms to which they are attached and the intervening carbon atom, each forms a 1,3-diazaheterocyclic radical of 5 to 7 atoms, which heterocyclic radicals may be the same or different; and m is 2 or 3; provided that R<1><0>, R<1><1>, R<1><2>, R<1><3>, R<1><4>, R<1><5>, R<1><6> and R<1><7> together contain 16 to 28 carbon atoms, and the acid addition salts thereof, processes for their manufacture and antibacterial and antifungal compositions and methods using said compounds. |
