摘要 |
PCT No. PCT/EP82/00010 Sec. 371 Date May 24, 1982 Sec. 102(e) Date May 24, 1982 PCT Filed Jan. 21, 1982 PCT Pub. No. WO82/02552 PCT Pub. Date Aug. 5, 1982.A process for the manufacture of imidazolylvinyl ethers of the formula <IMAGE> (I) wherein Im represents the substituted or unsubstituted 1-H-imidazol-1-yl group and An, R and Y are defined hereinbelow by condensation of a corresponding ketone of the formula Ar-CO-CHR-Im (II) with the splitting-off of a Z group, with a condensable substance of the formula Z-Y (III) in the aqueous solution of a strong inorganic base, preferably in concentrated aqueous soda lye. The reaction may also be carried out in the presence of a second liquid organic phase, preferably benzene or toluene, especially in the presence of a phase transfer catalyst in this case. Through careful crystallization of the product manufactured according to this method, it is possible to manufacture approximately pure E-isomers of the imidazolylvinyl ether of formula (I), without the requirement of chromatographic separation. |