| 摘要 |
Phenoxy-aminopropanol derivs. of formula (I) and their acid addn. salts were prepd. by reacting epoxides of formula (II) with amines of formula (II). In the formulas, R is lower alkyl; X is O or S; n is 0 or 1; Y is methylene, ethylene, or propylene or, when n is 0, y can also be -CH=CH-C*H2-, where the double bond is trans and C* is linked to Z; Z is 1-imidazolyl, 1H-1,2,4-triazol1-yl, 1H-1,2,3-triazol-1-yl, 2H-1,2,3-triazol-2-yl, 1-pyrazolyl, 4-chloro-1-pyrazolyl, 4-phenyl-1- pyrazolyl, 1-benzimidazolyl, 2H-benzotriazol-2-yl, 4,5,6,7- tetrahydro-2H-benzotriazol-2-yl, or 1H-indazol-1-yl; and Z is linked to Y at an N atom. The compds. have antihypertensive activity.
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