Benzofuran- and benzopyran-carboxamide derivatives.

摘要

Benzofuran- and benzopyran-carboxamide derivatives of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="32" wi="45" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein is ℓ 1 or 2; Xa is hydrogen atom, an amino group or a halogen atom; Y is -S(O)<Sub>m</Sub>-R<Sup>3</Sup> wherein R<Sup>3</Sup> is a lower alkyl group and m is 0, 1 or 2, or
<Chemistry id="chema02" num="0002"><Image id="ia02" he="9" wi="28" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sup>4</Sup> and R<Sup>5</Sup> are the same or different and are each a hydrogen atom or a lower alkyl group; R'is a hydrogen atom, a lower alkyl group, an arylthiomethyl group, a halogenomethyl group or
<Chemistry id="chema03" num="0003"><Image id="ia03" he="11" wi="30" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sup>6</Sup> and R<Sup>7</Sup> are the same or different and are each a hydrogen atom or a lower alkyl group or R<Sup>6</Sup> and R<Sup>7</Sup> together with the adjacent nitrogen atom form a heterocycle; R<Sup>2</Sup> is a hydrogen atom or a lower alkyl group; and Z is
<Chemistry id="chema04" num="0004"><Image id="ia04" he="10" wi="33" file="IMGA0004.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein pis 2 or 3, R<Sup>a</Sup> and R<Sup>9</Sup> are the same or different and are each a lower alkyl group or R<Sup>8</Sup> and R<Sup>9</Sup> together with the adjacent nitrogen atom form a heterocycle, or
<Chemistry id="chema05" num="0005"><Image id="ia05" he="35" wi="40" file="IMGA0005.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry><!-- EPO <DP n="2"> --> wherein q is 0 or 1, n is 1 or2, R<Sup>10</Sup> is a lower alkyl group, a lower alkenyl group, a lower alkinyl group, an aralkyl group or a cycloalkyl group and R<Sup>11</Sup> is a hydrogen atom or a lower alkyl group, their physiologically acceptable salts or their optical isomers, and a method of preparing same. These compounds are useful as psychotropic and antipsychotic agents.