Analogs of vasopressin

摘要

Vasopressin analogs of the formula wherein R1 is H, R2 is CH2S and R3 is D-Arg, R1 is NH2, R2 is S-S and R3 is D-Arg or L-Orn are described. The described analogs resist enzymatic cleavage while retaining their effect on the central nervous system. These compounds lack a glycinamide residue in the 9 position and have the L-arginine in the 8 position replaced with its stereoisomeric form or with an ornithine residue. The compounds evidence little or no peripheral endocrine effects of natural vasopressin.