CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES

摘要

Abstract The invention relates to a modified oligonucleotide comprising a structure shown below: Linker-LG Linker-LG Linker-LG 5 Linker-LG, Linker-LG, Linker-LG Linker-LG Linker-LG or Linker-LG LG is independently for each occurrence a ligand; and Z', Z", Z"' and Z"" are each independently for each occurrence 0 or S; and wherein all of the nucleotide 10 sugars of the RNA agent is modified, and to a method of modulating expression of a target gene using the modified oligonucleotide. 56228371 (GHMatters) P84321.AU.1 PETERB 31107/14