发明名称 Antifungal amide and urea derivatives of (3-amino-2-aryl-2-hydroxyprop-1-yl)-1H-1,2,4-triazoles
摘要 Compounds of the general formula <IMAGE> (I) or a pharmaceutically acceptable acid addition salt thereof, wherein R is naphthyl, biphenylyl, phenyl or substituted phenyl; and R1 is <IMAGE> where X is O or S, R2 is H, or C1-C4 alkyl and R3 is H, C1-C4 alkyl, C3-C6 cycloalkyl, optionally mono- or disubstituted phenyl, benzyl or Het and Het is pyridyl, pyrimidinyl or pyrazinyl; said substituents being halo, CF3, C1-C4 alkyl, C1-C4 alkoxy or hydroxy, or R2 and R3 taken together complete a 1-pyrrolidinyl or piperidino ring; methods for their use in combatting fungal infections in plants and animals, including humans; pharmaceutical and agricultural compositions containing them and intermediates useful in their preparation.
申请公布号 US4482558(A) 申请公布日期 1984.11.13
申请号 US19830500748 申请日期 1983.06.03
申请人 PFIZER INC. 发明人 RICHARDSON, KENNETH;WHITTLE, PETER J.
分类号 A01N43/653;A01N47/28;A01N47/30;A01N47/32;A01N47/36;A61K31/41;A61K31/44;A61K31/4427;A61K31/495;A61K31/505;A61P31/04;C07D209/08;C07D249/08;C07D401/12;C07D403/12;C07D413/06;C07D521/00;(IPC1-7):A01N43/64 主分类号 A01N43/653
代理机构 代理人
主权项
地址