主权项 |
1. A method of treating a sebum over-production condition in a subject in need wherein said method comprises topically administering a therapeutic amount of a visfatin antagonist to the subject in need; wherein said visfatin antagonist comprises:
a) FK-866; b) at least one siRNA comprising a nucleic acid sequence selected from the group consisting of SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 22, SEQ ID NO: 23, SEQ ID NO: 24, SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 9, SEQ ID NO:10, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 17, and SEQ ID NO: 18; or c) both (a) and (b) wherein the sebum over-production condition is selected from the group consisting of acne, seborrhea, seborrhoeic dermatitis, a sebaceous cyst and sebaceous hyperplasia. |