| 摘要 |
PURPOSE:To obtain the titled compound useful as a raw material and a synthetic intermediate of organic synthetic chemicals such as pharmaceuticals, agricultural chemicals, etc., in high yield, suppressing the production of by-products, by the hydration reaction of acrylonitrile in the presence of a tertiary amine catalyst and formamide. CONSTITUTION:The objective beta-hydroxypropionitrile is obtained by reacting acrylonitrile in an aqueous medium such as water, alcohol, etc. in the presence of formaldehyde or its oligomer (e.g. formalin, paraformaldehyde, etc.) at normal temperature -100 deg.C, preferably 40-80 deg.C, using a tertiary amine (e.g. triethylamine, triethanolamine, etc.) as a catalyst. The amount of the catalyst is 0.01- 0.5mol and that of formaldehyde is 0.5-20mol, preferably 1-10mol per 1mol of acrylonitrile.
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