| 摘要 |
Substituted picolinic acids of the general formula (I), wherein R<1> denotes alkyl with 1 to 7 carbon atoms - but not butyl if R<2> and R<3> denote alkyl and X denotes NH -, cycloalkylalkyl with 3 to 7 carbon atoms in the cycloalkyl part and 1 to 4 carbon atoms in the alkylene part, phenyl or substituted phenyl with up to three substituents from the group comprising halogen, hydroxyl, alkyl with 1 to 4 carbon atoms and alkoxy with 1 to 4 carbon atoms, R<2> denotes alkyl with 1 to 4 carbon atoms or alkenyl with 3 to 5 carbon atoms and R<3> denotes alkyl with 1 to 4 carbon atoms or alkenyl with 3 to 5 carbon atoms, or R<2> and R<3> together, and including the nitrogen atom to which they are bonded, denote pyrrolidino, morpholino, piperidino, hexahydroazepino, or 1-piperazinyl which is substituted in the 4-position by R<4>, R<4> denotes hydrogen, alkyl with 1 to 4 carbon atoms, phenyl, benzyl or substituted phenyl with up to three substituents from the group comprising halogen, hydroxyl, alkyl with 1 to 4 carbon atoms and alkoxy with 1 to 4 carbon atoms, A denotes straight-chain or branched alkylene with 1 to 5 carbon atoms and X denotes O (oxygen) or NH, and the acid addition salts of these compounds, R<1>, R<2> and R<3> not simultaneously denoting alkyl if X represents O (oxygen) and A represents ethylene, are new compounds with a hypotensive activity. Processes for the preparation of these compounds are described. |
