发明名称 |
MANUFACTURE OF FREEZE-DRY ADSORBED POLYHYDRIC VACCINE |
摘要 |
The invention relates to the preparation of lyophilized, absorbed polyvalent vaccines. According to the invention tetanus, diphtheria, pertussis and optionally typhus antigens concentrated to 5 to 15 doses/3 ml are adsorbed at a pH value of 3 to 6 to an insoluble carrier concentrated in the same way as the antigens, then the pH of the mixture is adjusted to a value of 5 to 6 and lyophilized together with a protective material commonly used in lyophilizing processes. Before administration the lyophilized vaccine is diluted to the concentration required by a physiological saline buffered to a pH value of 6.8 to 7 by a phosphate solution. |
申请公布号 |
JPS59196821(A) |
申请公布日期 |
1984.11.08 |
申请号 |
JP19840030463 |
申请日期 |
1984.02.22 |
申请人 |
FUMAN ORUTOANYAGUTERUMERO ESU KUTATO INTEZETO |
发明人 |
ZORUTAN TSUIZERU;KARORII SHIKOSU;RATSURO BATSUTSUKAI;ISUTOBAN ZOO;EREONORA NIIDERUMEIYAA;RAYOSU RESHII;YOSEFU TSUIDAI |
分类号 |
A61K39/00;A61K9/00;A61K9/14;A61K9/19;A61K39/05;A61K39/08;A61K39/10;A61K39/116;A61K47/26;A61K47/36 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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