Pharmaceutical composition comprising stem cells treated with NOD2 agonist or culture thereof for prevention and treatment of immune disorders and inflammatory diseases

摘要

The present invention relates to a pharmaceutical composition for the prevention or treatment of immune disorders and inflammatory diseases, comprising stem cells that are generated by culturing stem cells expression Nucleotide-binding Oligomerization Domain protein 2 (NOD2) with a NOD2 agonist or a culture thereof. More particularly, the present invention relates to a method for suppressing immune responses or inflammatory responses of a subject, comprising the step of administering the pharmaceutical composition, the stem cells or culture thereof to the subject, a method for preparing an immunosuppressive drug or an anti-inflammatory drug using the stem cells or culture thereof, a method for preparing PGE2 or TGF-β1 comprising the step of culturing NOD2-expressing stem cells in culture medium with a NOD2 agonist, a graft comprising stem cells expressing NOD2 and the NOD2 agonist, a method for preparing the graft, a composite comprising stem cells expressing NOD2 and the NOD2 agonist, and a culture generated by culturing the NOD2-expressing stem cells with a NOD2 agonist.

主权项

1. A method for suppressing immune responses or inflammatory responses of a subject comprising the steps of
(a) determining expression of Nucleotide-binding Oligomerization Domain protein 2 (NOD2) in isolated mesenchymal stem cells; (b) treating the cells expressing NOD2 with a NOD2 agonist to increase the production of prostaglandin E2 (PGE2) or transforming growth factor beta 1 (TGF-β1) and culturing them; and (c) providing the cells producing PGE2 or TGF-β1 of step (b) or a culture thereof to the subject.