| 摘要 |
<p>Compounds which may be used as antagonists of the antidiuretic action of arginine vasopression have the formula: <CHEM> in which: X is (D- or L-)Tyr(R) (in which R is methyl, ethyl, propyl or butyl), D-Tyr, D-Phe, D-Val, D-Leu, D-Ile, D-Arg, D-Gln, D-Asn, D-NVa, D-Nle, D-Cha, D-Abu, D-Thr or D-Met; Y is (D- or L-)Cys; W is (D- or L-)Pro, DELTA <3>-Pro, or HO-Pro; Z is (D- or L-)Arg, (D- or L-)Lys or (D- or L-)Orn; and n is 4 or 5; provided that when X is other than D-Gln or D-Arg, W is Pro, Y is Cys and Z is (D- or L-)Arg, n is 4; and when X is (D- or L-)Tyr(R) and n is 5, W is HO-Pro or D-Pro.</p> |
