| 摘要 |
NEW MATERIAL:The compound of formula I (R<1> is methyl or ethyl; R<2> and R<4> are H or 1-7C alkyl; R<3> is H, 1-4C alkyl, hydroxymethyl, mercaptomethyl, or 2-methylthioethyl; n is 1-5; provided that when n is 2-5, R<3> is H). EXAMPLE:N-(1-Methylcyclohexanecarbonyl)glycine ethyl ester. USE:Useful as a hepatic function improving agent, an antithrombotic agent, and a remedy for diseases caused by immune abnormality, e.g. arthrorheumatism, autoimmune diseases, allergic diseases such as asthma, nephritis, etc. PREPARATION:The compound of formula I can be prepared by reacting the compound of formula II with a halogenation agent (e.g. thionyl chloride, phosphorus pentachloride, etc.), and reacting the resultant compound of formula III with the compound of formula IV in the presence of a base (e.g. triethylamine).
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