| 摘要 |
PURPOSE:To obtain the titled comound useful as a raw material and synthetic intermediate of organic synthetic chemicals such as pharmaceuticals, agricultural chemicals, etc., in high yield, suppressing the production of by-products, by the hydration reaction of a dilute acrylonitrile in the presence of a strongly basic ion exchange resin catalyst. CONSTITUTION:The objective beta-hydroxypropionitrile is obtained by reacting acrylonitrile having a concentration of <=10wt%, preferably 7-1wt% in an aqueous medium such as water, alcohol, etc. in the presence of a strongly basic ion exchange resin catalyst consisting of a crosslinked polyvinylbenzyl trimethyl ammonium salt (e.g. Amberlite IRA-400) at normal temperature -100 deg.C, preferably 40-80 deg.C. The amount of the catalyst is preferably 5-30wt% based on the reaction liquid, and the catalyst can be used repeatedly. |
