Osteoinductive demineralized cancellous bone

摘要

An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents.

主权项

1. An osteoinductive composition comprising: at least partially demineralized cancellous bone, the at least partially demineralized cancellous bone having been treated with collagenase to digest or modify a percentage of collagen fibers of said partially demineralized cancellous bone and to increase the osteoinductive activity of the bone; wherein the at least partially demineralized cancellous bone exhibits increased osteoinductive activity when compared to untreated at least partially demineralized cancellous bone.