PROSTAGLANDINS

摘要

Novel compounds have a formula (I) represents a bicyclo [2,2,1] hept-2Z-ene, bicyclo [2,2,1] heptane, 7-oxabicyclo [2,2,1] hept-2Z-ene, 7-oxabicyclo [2,2,1] heptane, bicyclo [2,2,2] oct-2Z-ene or bicyclo [2,2,2] octane substituted at the 5-position by the group R<1> and at the 6-position by the group C(R<2>)=NR, a 6,6-dimethyl-bicyclo [3,1,1] heptane substituted at the 5-position by the group R<1> and at the 6-position by the group C(R<2>)=NR or at the 5-position by the group C(R<2>)=NR and at the 6-position by the group R<1>, a cyclohex-1-ene or cyclohexane substituted at the 4-position by the group R<1> and at the 5-position by the group C(R<2>)=NR, or a 1-hydroxycyclopentane substituted at the 2-position by the group R<1> and at the 2-position by the group C(R<2>)=NR, R<1> is a 6-carboxyhex-2-enyl group or a modification thereof as defined herein, R<2> is hydrogen, an aliphatic hydrocarbon group or an aliphatic hydrocarbon group substituted directly or through an oxygen or sulphur atom by an aromatic group, and R is a group -OR<3>, -OR<4>, -A-R<3> or -N=R<5> in which A is -NH-, -CH.CO-, -NH.CO.CH2N(R<6>)-, -NH.SO2-, -NH.CO.NH or -NH.CS.NH- and wherein R<3> is an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted directly or through an oxygen or sulphur atom by an aromatic group, R<4> is an aliphatic hydrocarbon group which is substituted through an oxygen atom by an aliphatic hydrocarbon group which is itself substituted by an aromatic group, R<5> is an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted directly or through an oxygen or sulphur atom by an aromatic group, and R<6> is hydrogen, an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted directly or through an oxygen or sulphur atom by an aromatic group, with the proviso that when R is a group -OR<3>, -NH.COR<3> or -NH.CO.NHR<3> then excludes bicyclo [2,2,1] hept-2Z-enes and bicyclo [2,2,1] heptanes. The compounds are of value for use in pharmaceutical compositions particularly in the context of the inhibition of thromboxane activity.