PROCESS FOR THE PREPARATION OF LIPOSOMAL MEDICAMENTS

摘要

Associates of at least one amphiphilic bilayer-forming substance and a solubilizing agent are formed in an aqueous phase. The bilayerforming substance itself can be a pharmaceutical substance, or pharmaceutical substances and/or pharmaceutical auxiliaries may be added. The novel process for preparing liposomal medicaments from such aqueous phase comprises increasing the molar ratio of the bilayer-forming substance to the solubilizing agent in such associates, at a rate which is essentially constant in time and location and which is sufficiently high for the associates to combine to form liposomes, essentially all of which have a predetermined number of double layers, and which have a predetermined essentially homogeneous size. The liposomes thereby achieve a predefined, virtually homogeneous size.