发明名称 |
TRANFORMED VIBRIO CHOLERAE AS VACCINE |
摘要 |
Plasmids and modified strains of Vibrio cholerae are prepared which are a genetically stable nontoxinogenic form of Vibrio cholerae which has a deletion mutation in both copies of the A1-peptide-encoding gene, resulting in the loss of a gene sequence required for expression of a toxic A1 peptide. The modified strains are useful as live or dead oral vaccines. |
申请公布号 |
AU2727084(A) |
申请公布日期 |
1984.11.01 |
申请号 |
AU19840027270 |
申请日期 |
1984.04.26 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
JOHN J. MEKALANOS |
分类号 |
C12N15/09;A61K39/106;C07K14/28;C12N1/20;C12N1/21;C12N15/00;C12N15/01;C12R1/63 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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