| 摘要 |
NEW MATERIAL:A compound of formula I (R1 is H, methyl or ethyl; R2 is lower alkyl; n is 2 or 3) and a pharmacologically acceptable salt thereof. EXAMPLE:N-[2-(N',N'-Dimethylamino)ethyl]-3-methylflavone-8-carboxamide. USE:A remedy for disorder in urinary tracts, having improved action on the urinary bladder, e.g. papaverine like action, inhibitory action on urinary reflex, contraction action on the urinary bladder, etc. and useful for treating the disorder in the urinary tracts, e.g. thamuria. PROCESS:At least one equivalent or more preferably 1.1 equivalents, flavone-8- carboxylic acid halogenide derivative of formula II (X is halogen) is reacted with one equivalent diamine derivative of formula III in an organic solvent, e.g. acetone or ether, to give the aimed compound of formula I . |
