| 摘要 |
<p>A chemical process is described for the preparation of H2-anthagonists or precursors thereof. of the formula (V): <CHEM> wherein R<1> is 5-methylimidazol-4-yl, furan-2-yl or 5-dimethylaminomethylfuran-2-yl and R<2> is 3,4-methylenedioxyphenyl or optionally protected 2-hydroxypyrid-4-yl; which process comprises reacting a compound of the formula (VI) with a compound of the formula (VII): <CHEM> wherein R<3> is C1-6alkyl; and thereafter if desired deprotecting a protected hydroxy group, converting a compound wherein R<1> is furan-2-yl into a compound wherein R<1> is 5-dimethylaminomethylfuran-2-yl, and/or forming a pharmaceutically acceptable salt.</p> |
