摘要 |
<p>Nitroaralkyl cyanides are prepared by reacting a nitroaromatic compound with an alpha,alphadisubstituted acetonitrile in a substantially anhydrous aprotic solvent and in the presence of a base so that the nitrile undergoes a nucleophilic substitution on an unsubstituted ring carbon of the halonitro aromatic compound during which an alpha-substituent functions as a leaving group. The nitroaralkyl cyanides formed by the process can be readily converted into derivatives, such as pharmaceuticals.</p> |