| 摘要 |
NEW MATERIAL:The compound of formula I [R<1> is alkylene or arylene (which may be substituted with acylmercapto or nitro) or -X-O-X'- (X and X' are alkylene); R<2> is OH, lower alkoxy, -SO2H or -SO3H; R<3> is lower alkyl; R<4> is group of formula II or III] and its salt. EXAMPLE:5,10,11,11a-Tetrahydro-9-(3-succinimidoxycarbonylpropanoyloxy) -11-hydroxy-8-methyl-5-oxo-1H-pyrrolo[2,1-C][1,4]benzodiazepine-2-acry lamide. USE:Intermediate for the synthesis of drug such as antitumor agent. PREPARATION:The objective compound can be prepared e.g. by reacting the compound of formula IV with N-hydroxysuccinimide or N-hydroxy-5-norbornene- 2,3-dicarboximide preferably at 0-30 deg.C.
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