| 摘要 |
Cyclohexylpiperidines I (R = OH, esterified OH, amino; R1 = H, alkyl; Ar1, Ar2 = optionally substituted Ph, thienyl, pyridyl) were prepared. Thus, 4-oxo-1-(2-piridinyl)cyclohexanecarbonitrile was treated with Et 4-phenyl-4-piperidinecarboxylate, followed by redn., to give I (R = OEt, R1 = H, Ar1 = 2-pyridinyl, Ar2 = phenyl). I have antihistaminic acitivity. Thus, I (R = OEt, R1 = H, Ar1 = 4-FC6H4, Ar2 = phenyl) protected rats against the lethal effects of compounds 48/80 at 0.04 mg/kg orally.
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