摘要 |
Antidepressant pharmaceuticals comprise the title compds. I (R1 = H or C1-3 alkyl; R2 = C1-3 alkyl; Z = substituted Ph; W = H, Br, Cl, F, CF3, and C1-3 alkoxy) and their salts. I were prepd. by stepwise reaction either from the base-catalyzed stobble condensation of a substituted benzophenone with di-Et succinate, or from the condensation of a hydroxytetralone with the appropriate secondary amine in the presence of an acid catalyst. Thus, a tablet formulation contained by wt. cis-(1s)-N-methyl-4-(3,4dichlorophenyl)-1,2,3,4- tetrahydro-1-naphthalenamine-HCl 50, Na citrate 25, alginic acid 10, poly(vinylpyrrolidone) 10, and Mg stearate 5.
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