摘要 |
2-(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazole I (R1 = alkyl; R3 = alkyl, acetyl, ethoxy - carbonyl; X = halo.) was prepd. as a treatment material for gastric ulcers. Thus, 3,4,5trimethoxythiobenz amide was treated with -halogeno-3,4,5trimethoxythiobenz amide was treated with -halogenoketone II to give I. This reaction was carried out at 20-200≦̸C for 1-10 hrs. using a non-functional solvent, such as benzene, toluene, or xylene. In toxicological expts., LD50 was over 5g/kg in rats.
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