| 摘要 |
<p>New traizine derivatives represented by the formula:
<CHEM>
wherein R<1> is hydrogen; halogen or hydrazinocarbonyl (lower) alkyl;
R<2> is hydrazino;
azido;
halosulfonyl;
mono- or di(lower)alkylamino;
mono- or di-(lower)alkynylamino;
pyridylamino;
lower alkylideneamino substituted by furyl pyridyl or aryl;
mono- or di-(lower) alkylamino substituted by amino, carboxy, hydroxy, ureido, lower alkoxy, lower alkoxycarbonyl, lower alkoxy (lower) alkoxy, aryl, furyl, pyridyl, phthalimido, or succinimido;
N-methyl (lower) alkanoylamino;
N-containing, 5- or 6-membered heterocyclic group optionally substituted by oxo, lower alkyl and/or lower alkoxycalbonyl;
lower alkoxy substituted by hydroxy and lower alkylamino; or
a group of the formula
<CHEM>
in which R<3> is hydrogen; lower alkyl or ar (lower) alkyl;
R<4> is pyridyl; aryl; styryl;
alkynyl; lower alkoxycarbonyl;
alpha -hydroxybenzyl; lower alkanoyl; carboxy; or lower alkyl substituted by halogen, amino, hydroxy, carboxy, lower alkanoyl, lower alkanoyloxy, lower alkoxycarbonyl, morpholino, lower alkoxycarbonylamino, 1-methyl-2-oxo-1, 2, 3, 4-tetrahydroquinolyloxy, mono- or di(lower)alkylamino, piperazinyl being substituted with hydroxy(lower)alkyl or furoyl, or pyrrolidino;
and pharmaceutically acceptable salt thereof, which are useful in the treatment of hypertension, thrombosis and ulcer in human beings and animals. </p> |
