| 摘要 |
NEW MATERIAL:A compound of formula I (R1 is H, lower alkyl; R2 is H, lower alkyl, aralkyl; R3 is H, hydroxyl; R1 and R2 may incorporate together with an N atom to form a 5-13 membered alkyleneimino). EXAMPLE:20-Deoxy-20-dimethylaminomycaminosylrelonolide. USE:Antibacterial against gram-positive and -negative bacteria. PREPARATIONThe reaction between 20-deoxy-20-halo-mycarminosylrelonolide of formula II and an equimolar or exessive molar amount of an amine of formula IIIis carried out with heat under reflux in an inert solvent such as THF, followed by deprotection.
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