| 摘要 |
1-oxadethia cephalosporin derivatives I (R = 1-methyl-1Htetrazol-5- ilthio, 2-carboxymethylhydroxy-1H-tetr-azol-5-il thio, 4-methyl-5- oxo-6-hydroxy-4,5-dihydro-1,2,4-triazine-3-ilthio, pyridium, 4- carbamoyl-pyridium, 1-dimethylaminoethyl-1-H-tetrazol-ilthio, (un) substituted-tetrazole-(1,5-b)-pyridazine-6-ilthio; Y = H, methoxy; R1 = H, protected carboxy; Z = halo; X = 1-3) were prepd. Thus, II was treated with III to give I. I has bactericidal activity both in vivo and in vitro. Also, it is connected with the chemotherapeutic use of the bactericidal composition containing I derivatives.
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