| 摘要 |
The title compds. I(R = alkyl, haloaralkyl, CH2N3, CH2SO2 Me; Z = H, acyl; X = H, halo, NO2, alkoxy, alkylthio, alkanoyl, alkanesulfinyl, alkanesulfonyl, substituted aminosulfinyl or sulfamoyl) and pharmaceutically acceptable salts of I [Z = carboxysubsti-tuted acyl, amino-substituted acyl (derived from amino acid) were prepared by different methods and exhibited bactericidal activity. When the product was treated with Et2NH-BF3 adduct, the D-threo-1-(4- nitrophenyl)-2-phthalimido-3-fluoro-1propanol obtained was then subjected to hydrazinolysis and the primary amine product reacted with Cl2CHCO2 Me to give I (R = CHCl2, X = NO2, A = H).
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