PROCESS FOR PREPARING 7-ACYL AMIDA -3-VINYL CEPHALOSPORANIC ACID DERIVATIVES

摘要

Nine cephalosporanic acid derivatives (I; R1 = aminothiazolyl; R2 = carboxy, protected carboxy; A = carbonyl,-C=N-OR3; R3 = carboxyalkyl, protected carboxyalkyl) as the syn isomers were prepared. I were effective bactericides at 50-2000 mg/day. Thus, 0.683 g (H2N)2CS and 1.84 g NaOAc were added to a suspension of 2.0 g syn-II (I; A = -C=N=OCH2CO2Me) in H2O at 40≦̸ and stirred 1.5 hr. to give 1.9 g syn-I (R = 2-aminothiazol 4-yl, R3 = MeO2CCH2; R2 = HO2C).