3,8-DI(1,2-DIHYDROXYETHYL)DEUTEROPORPHYRIN

摘要

NEW MATERIAL:3,8-Di(1,2-dihydroxyethyl)deuteroporphyrin shown by the formula and its salt. USE:Useful as a laser photosensitizer having affinity for tumor. Synthesizable purely and easily. PREPARATION:A protoporphyrin dialkyl ester is reacted with osmium tetroxide to give an addition product, which is hydrolyzed, so that two vinyl group of the protoporphyrin dialkyl ester is converted into a dioxy derivative, which is de- esterifed by hydrolysis, to give a compound shown by the formula.