| 摘要 |
Imidazo[1,2-a] pyridines of the formula: <IMAGE> and their acid addition salts in which Y represents a hydrogen or halogen atom or a C1-4 alkyl radical, Z represents a naphthyl radical or a radical <IMAGE> in which each of X1 and X2 independently of one another is a hydrogen or halogen atom, a C1-4 alkoxy radical, a C1-6 alkyl radical or CF3, CH3S-, CH3SO2-, -NO2, -NH2 or -NHCOCH3, and each of R1 and R2 independently of one another represents a hydrogen atom, a straight or branched C1-5 alkyl radical which is unsubstituted or substituted by one or more halogen atoms or hydroxyl, -N(C1-4 alkyl)2, carbamoyl or C1-4 alkoxy radicals, allyl, propargyl, a C3-6 cycloalkyl radical, benzyl, or phenyl, not both R1 and R2 being hydrogen, or -NR1R2 represents a heterocyclic ring containing from 3 to 6 carbon atoms, or a heterocyclic ring of the formula <IMAGE> in which X is O, S, CHOR' or >N-R, R' being hydrogen or benzyl and R being hydrogen, a C1-4 alkyl radical, or phenyl which is unsubstituted or substituted by methoxy or a halogen atom, which may be made from the corresponding acids, have valuable pharmacological properties, especially anxiolytic, anti-anoxic, sleep-inducing, hypnotic and anticonvulsant properties. |
