摘要 |
The present invention relates to novel pharmaceutical compositions having antiepileptic and antineuraglic action and containing (a) at least one anticonvulsive compound of the general formula I <IMAGE> (I) wherein X1 is hydrogen, halogen having an atomic number up to 35, or is cyano, and X2 and Y together are an additional bond, or X1 and X2 together are the oxo radical, or X1 is hydroxy, X2 is hydrogen and Y is also hydrogen, and (b) at least one nootropic compound of the vincamine type which has the general formula II <IMAGE> (II) wherein Z1 is lower alkoxycarbonyl, Z2 is hydroxy and Z3 is hydrogen, or Z2 and Z3 together are an additional bond, or one of Z1 and Z2 is hydroxy and the other is hydrogen and Z3 is also hydrogen, in particular vincamine (DCI rec.), in which Z1 is methoxycarbonyl, Z2 is hydroxy and Z3 is hydrogen, and also e.g., vinpocetin (DCI rec.), in which Z1 is ethoxycarbonyl and Z2 and Z3 together form an additional bond, as well as vincanol (DCI prop.), in which one of Z1 and Z2 is hydroxy and the other is hydrogen and Z3 is hydrogen, and the acid addition salts thereof, or at least one nootropic derivative of 2-pyrrolidinone, e.g. 2-oxo-1-pyrrolidineaetamide (piracetam) or one of its nootropic derivatives. The compounds of the general formula II e.g. vincamine, as well as the nootropic derivatives of 2-pyrrolidinone, e.g. piracetam, have in themselves virtually no anticonvulsive activity but potentiate the action of the compounds of the general formula I, e.g. carbamazepine. |