| 摘要 |
PCT No. PCT/GB81/00058 Sec. 371 Date Nov. 23, 1981 Sec. 102(e) Date Nov. 23, 1981 PCT Filed Mar. 26, 1981 PCT Pub. No. WO81/02667 PCT Pub. Date Oct. 1, 1981.Surgical implants, especially endoprosthetic orthopaedic implants and sutures, are rendered antimicrobial by the presence of a bioerodible metallic silver component, especially a surface coating, which provides in vivo a sustained release of silver ions in a concentration sufficient to provide a localized antimicrobial effect but insufficient to cause significant damage to connective tissue. Latently bioerodible silver components of an implant can be activated by, for example, abrasion, heating to above about 180 DEG C. or, especially, contact with hydrogen peroxide.
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