| 摘要 |
Title compds. (I; R1=H, C1-4 lower alkyl, C1-4 lower alkoxy, halogen; Y=(CH2)n; n=1-4; Z=CO2R2, CONHR3, CN, tetrazoly; R2=H, C1-4 alkyl; R3=h, C1-4 alkyl) useful in the inhibition of thromoboxane syntheetase, were prepd. by the reaction of III and the reaction products obtained from II with alkali metal hydride. Thus, 4.95g 2-dimethylaminoethyl-4-methylphenol reacted with 2.04g imidazole, and the product was treted NaH(1.50g) and ethylbromo0avetate(5.04g) at room temp for 2 hr to give 5.3g 2-(l-imidazolymethyl)-4-methyl-phenoxyacetic ethyl ester.
|
